An analytic study on the effect of alginate on the velocity profiles of blood in rectangular microchannels using microparticle image velocimetry.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24023655.
- Also identified by DOI 10.1371/journal.pone.0072909 and PMC identifier 3758353.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
It is desired to understand the effect of alginic acid sodium salt from brown algae (alginate) as a viscosity modifier on the behavior of blood in vitro using a micro-particle image velocimetry (µPIV) system. The effect of alginate on the shape of the velocity profile, the flow rate and the maximum velocity achieved in rectangular microchannels channels are measured. The channels were constructed of polydimethylsiloxane (PDMS), a biocompatible silicone. Porcine blood cells suspended in saline was used as the working fluid at twenty percent hematocrit (H = 20). While alginate was only found to have minimal effect on the maximum velocity and the flow rate achieved, it was found to significantly affect the shear rate at the wall by between eight to a hundred percent.
Medical subject headings
- Alginates
- Microfluidics
- Microspheres
- Rheology