Did a classic preconditioning study provide a clue to the identity of the mitochondrial permeability transition pore?
Where this comes from
- Record sourced from PubMed, PMID 24030020.
- Also identified by DOI 10.1161/CIRCRESAHA.113.301950 and PMC identifier 4180419.
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Abstract
A classic paper by Murry, Richard, Reimer and Jennings published in 1990 in Circulation Research showed that preconditioning showed the rate of ATP breakdown during a subsequent sustained period of ischemia. The mechanism responsible for reduced ATP breakdown is still unknown, but perhaps it is related to inhibition of the F1-F0 ATPase. This is an attractive hypothesis given a number of recent studies suggesting that the F1-F0 ATPase can form the mitochondrial permeability transition pore.
Medical subject headings
- Ischemic Preconditioning, Myocardial
- Mitochondrial Membrane Transport Proteins