Response to Comment on "Influence of HLA-C expression level on HIV control".
Level V
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- Record sourced from PubMed, PMID 24031003.
- Also identified by DOI 10.1126/science.1241854 and PMC identifier 6314016.
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Abstract
Lo Monaco et al. propose that human leukocyte antigen E (HLA-E) and HLA-C expression levels both contribute to HIV control. The minimal, flat level of cell surface HLA-E detectable by staining with available HLA-E-specific antibodies questions a role for differential HLA-E expression in determining HIV control. Evidence remains far stronger that HLA-C expression levels as detected by the DT9 antibody specifically affect HIV control.
Medical subject headings
- Gene Expression Regulation
- HIV
- HIV Infections
- HLA-C Antigens
- T-Lymphocytes, Cytotoxic