A template for new drugs against Alzheimer's disease.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 24034239.
- Also identified by DOI 10.1016/j.cell.2013.08.049.
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Abstract
Alzheimer's disease (AD) is associated with the deposition of β-amyloid (Aβ) plaques in the brain. In this issue, by cleverly processing patient samples, Lu et al. define a novel structural model of Aβ fibrils from AD brain, revealing surprising differences from in vitro fibrils. These findings may lead to structure-specific inhibitors and more selective amyloid-imaging methods.
Medical subject headings
- Alzheimer Disease
- Amyloid
- Brain