Self-eating limits EGFR-dependent tumor growth.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24034240.
- Also identified by DOI 10.1016/j.cell.2013.08.040.
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Abstract
Autophagy is a cell-autonomous, catabolic process that plays context-dependent roles in tumor growth and progression. Wei et al. report that EGFR signaling promotes tumor growth through phosphorylation and functional inactivation of Beclin 1 and the consequent suppression of autophagy.
Medical subject headings
- Apoptosis Regulatory Proteins
- Autophagy
- Drug Resistance, Neoplasm
- ErbB Receptors
- Membrane Proteins