Intrinsic activity of odorant receptors guides sensory map formation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24034241.
- Also identified by DOI 10.1016/j.cell.2013.08.037 and PMC identifier 3865890.
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Abstract
Olfactory sensory neurons innervate the olfactory bulb in stereotyped patterns according to the odorant receptors they express. A study by Nakashima et al. in this issue demonstrates that the odorant receptor's level of intrinsic activity-in the absence of activating odorant-influences the guidance of olfactory axons to their targets.
Medical subject headings
- Axons
- Olfactory Pathways
- Receptors, Odorant
- Sensory Receptor Cells