Long noncoding RNAs usher in a new era in the biology of enhancers.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24034243.
- Also identified by DOI 10.1016/j.cell.2013.08.028 and PMC identifier 4108076.
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Abstract
Enhancer-associated long noncoding RNAs act over long distances and across chromosomes to activate transcription at distal promoters. Here, we address the latest advances made toward understanding the role of long noncoding RNA expression and the involvement of these RNAs in enhancer function through association with protein factors and modulation of chromatin structure.
Medical subject headings
- Enhancer Elements, Genetic
- RNA, Long Noncoding
- Transcriptional Activation