Exploiting tertiary structure through local folds for crystallographic phasing.
basic_science · Level V
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- Record sourced from PubMed, PMID 24037245.
- Also identified by DOI 10.1038/nmeth.2644.
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Abstract
We describe an algorithm for phasing protein crystal X-ray diffraction data that identifies, retrieves, refines and exploits general tertiary structural information from small fragments available in the Protein Data Bank. The algorithm successfully phased, through unspecific molecular replacement combined with density modification, all-helical, mixed alpha-beta, and all-beta protein structures. The method is available as a software implementation: Borges.
Medical subject headings
- Crystallography
- Protein Folding
- Protein Structure, Tertiary