Three-dimensional microscaffolds exhibiting spatially resolved surface chemistry.
basic_science · Level V
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- Record sourced from PubMed, PMID 24038437.
- Also identified by DOI 10.1002/adma.201302678.
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Abstract
Spatial control over the surface chemistry of 3D organic-inorganic hybrid microscaffolds is achieved by a two-photon-triggered cycloaddition. Following a coating step with photoactivatable dienes via silanization, surface irradiation with a femtosecond-pulsed laser in the presence of functional dienophiles enables a site-selective alteration of the surface chemistry. Bioconjugation with fluorescent protein tags is employed to reveal the 3D molecular patterns.