Precise patterning of silk microstructures using photolithography.
basic_science · Level V
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- Record sourced from PubMed, PMID 24038619.
- Also identified by DOI 10.1002/adma.201302823.
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Abstract
Photolithography is used in conjunction with a "silk fibroin photoresist" to form precise protein microstructures directly and rapidly on a variety of substrates. High-resolution features in two and three dimensions with line widths down to one micrometer are formed. Photo-crosslinked protein structures guide cell adhesion, providing precise spatial control of cells without requiring adhesive ligands.