Phenotypic alteration of neutrophils in the blood of HIV seropositive patients.
Where this comes from
- Record sourced from PubMed, PMID 24039734.
- Also identified by DOI 10.1371/journal.pone.0072034 and PMC identifier 3767740.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
We have recently identified a novel population of activated low-density granulocytes (LDGs) in peripheral blood mononuclear cells of HIV seropositive patients. LDGs have a similar morphology to normal density granulocytes (NDGs), but are phenotypically different. Here we measured the expression levels of different phenotypic markers of granulocytes in the blood of HIV seropositive patients at different stages of HIV infection to determine whether the phenotype of NDGs and LDGs are affected by disease severity. Our results reveal that the phenotype of NDGs, but not that of LDGs, varies according to the severity of the disease.
Medical subject headings
- HIV Infections
- HIV-1
- Neutrophils