Hidden mastocytosis in acute myeloid leukemia with t(8;21)(q22;q22).
retrospective_cohort · Level III
Where this comes from
- Record sourced from PubMed, PMID 24045550.
- Also identified by DOI 10.1309/AJCP1Q0YSXEAHNKK.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
To assess the frequency of systemic mastocytosis (SM) in a large series of acute myeloid leukemia (AML) with t(8;21)(q22;q22). We retrospectively characterized 40 bone marrow aspirate smears and biopsy specimens from patients with AML with t(8;21) for the presence of SM. Cases were assessed for mast cell morphology and immunohistochemistry, as well as KIT exon 8 and 17 mutational assessment by reverse transcription polymerase chain reaction. Four patients met criteria for SM, 1 met criteria for myelomastocytic leukemia, and 8 demonstrated the benign finding of mast cell hyperplasia. We recommend examining all cases of AML with t(8;21) for the presence of SM via morphology, immunophenotyping, and KIT mutational analysis studies.
Medical subject headings
- Chromosomes, Human, Pair 21
- Chromosomes, Human, Pair 8
- Leukemia, Myeloid, Acute
- Mastocytosis, Systemic
- Translocation, Genetic