CD200 flow cytometric assessment and semiquantitative immunohistochemical staining distinguishes hairy cell leukemia from hairy cell leukemia-variant and other B-cell lymphoproliferative disorders.
other · Level V
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- Record sourced from PubMed, PMID 24045551.
- Also identified by DOI 10.1309/AJCPEBK31VQQNDDR.
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Abstract
To evaluate CD200 expression in B-cell proliferative disorders. We analyzed 180 recent specimens of B-cell neoplasms for CD200 expression by flow cytometric immunophenotypic analysis, which is better able to assess relative intensity of staining than immunohistochemical staining. We found that hairy cell leukemia exhibits a high level of staining for CD200 in comparison to other B-cell lymphoproliferative disorders, including hairy cell leukemia-variant (HCL-V), marginal zone lymphoma, and lymphoplasmacytic lymphoma. We confirmed this observation by semiquantitative immunohistochemical staining. Assessment of the CD200 expression level is helpful to distinguish HCL from HCL-V and other B-cell lymphoproliferative disorders and in the differential diagnosis of B-cell neoplasms in general.
Medical subject headings
- Antigens, CD
- Flow Cytometry
- Immunohistochemistry
- Leukemia, Hairy Cell
- Lymphoma, B-Cell, Marginal Zone
- Waldenstrom Macroglobulinemia