RNA-Pareto: interactive analysis of Pareto-optimal RNA sequence-structure alignments.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24045774.
- Also identified by DOI 10.1093/bioinformatics/btt536.
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Abstract
Incorporating secondary structure information into the alignment process improves the quality of RNA sequence alignments. Instead of using fixed weighting parameters, sequence and structure components can be treated as different objectives and optimized simultaneously. The result is not a single, but a Pareto-set of equally optimal solutions, which all represent different possible weighting parameters. We now provide the interactive graphical software tool RNA-Pareto, which allows a direct inspection of all feasible results to the pairwise RNA sequence-structure alignment problem and greatly facilitates the exploration of the optimal solution set.
Medical subject headings
- Algorithms
- Computational Biology
- RNA
- Sequence Alignment
- Sequence Analysis, RNA
- Software