High frequency of false-positive hepatitis C virus enzyme-linked immunosorbent assay in Rakai, Uganda.

Mullis, Caroline E; Laeyendecker, Oliver; Reynolds, Steven J; Ocama, Ponsiano; Quinn, Jeffrey; Boaz, Iga; Gray, Ronald H; Kirk, Gregory D et al. · Clin Infect Dis · 2013

cross_sectional · Level IV

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Abstract

The prevalence of hepatitis C virus (HCV) infection in sub-Saharan Africa remains unclear. We tested 1000 individuals from Rakai, Uganda, with the Ortho version 3.0 HCV enzyme-linked immunosorbent assay. All serologically positive samples were tested for HCV RNA. Seventy-six of the 1000 (7.6%) participants were HCV antibody positive; none were confirmed by detection of HCV RNA.

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