Application of [18F]FDG in radiolabeling reactions using microfluidic technology.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24056916.
- Also identified by DOI 10.1039/c3lc50797a.
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Abstract
Radiolabeling of peptides with the short-lived positron emitter fluorine-18 is usually a challenging endeavour. Conventional radiolabeling reactions mostly require fairly large amounts of peptides as labeling precursors, and extensive synthesis times. Intrinsic advantages of microfluidic technology permit to overcome these hurdles. Herein, we describe how microfluidic technology combined with [(18)F]FDG as readily available PET radiotracer allows for fast and high yielding radiolabeling reactions of peptides with fluorine-18.
Medical subject headings
- Fluorodeoxyglucose F18
- Microfluidic Analytical Techniques
- Peptides
- Radiopharmaceuticals