Curbing false discovery rates in interpretation of genome-wide expression profiles.
Where this comes from
- Record sourced from PubMed, PMID 24060601.
- Also identified by DOI 10.1016/j.jbi.2013.09.004.
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Abstract
Fisher's exact test is widely used in biomedical research, particularly in genomic profile analysis. Since in most databases, the frequency distribution of genes is right skewed, we show here that its use can lead to excessive false-positive discoveries. We propose to apply Zelen's exact test on a stratification of the gene set; this solves the false discovery problem, and should avoid misleading interpretations of lists of genes produced by various genome-wide analysis technologies.
Medical subject headings
- Gene Expression Profiling
- Genome-Wide Association Study