Rapamycin, anti-aging, and avoiding the fate of Tithonus.
Level V
Where this comes from
- Record sourced from PubMed, PMID 24063054.
- Also identified by PMC identifier 3726178.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The discovery that rapamycin increased the lifespan of mice was recognized by Science as one of the top 10 scientific breakthroughs of 2009. In addition to increasing lifespan, Neff and colleagues show that while rapamycin improves several functions/pathologies that change with age, it has little effect on the majority of the physiological and structural parameters they evaluated. What do these data tell us about the ability of rapamycin to delay aging and improve quality of life, i.e., prevent the fate of Tithonus?
Medical subject headings
- Aging
- Longevity
- Sirolimus
- TOR Serine-Threonine Kinases