Point-of-care diagnosis and prognostication of cryptococcal meningitis with the cryptococcal antigen lateral flow assay on cerebrospinal fluid.
cross_sectional · Level IV
Where this comes from
- Record sourced from PubMed, PMID 24065327.
- Also identified by DOI 10.1093/cid/cit641 and PMC identifier 3864499.
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Abstract
The cryptococcal antigen (CRAG) lateral flow assay (LFA) had 100% sensitivity and specificity on cerebrospinal fluid samples. Pretreatment LFA titers correlated with quantitative cultures (R(2) = 0.7) and predicted 2- and 10-week mortality. The CRAG LFA is an accurate diagnostic assay for CSF and should be considered for point-of-care diagnosis of cryptococcal meningitis.
Medical subject headings
- Cerebrospinal Fluid
- Chromatography, Affinity
- Cryptococcus
- Meningitis, Cryptococcal
- Point-of-Care Systems