ACMG Standards and Guidelines for constitutional cytogenomic microarray analysis, including postnatal and prenatal applications: revision 2013.
Level V
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- Record sourced from PubMed, PMID 24071793.
- Also identified by DOI 10.1038/gim.2013.129.
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Abstract
Microarray methodologies, including array comparative genomic hybridization and single-nucleotide polymorphism-detecting arrays, are accepted as an appropriate first-tier test for the evaluation of imbalances associated with intellectual disability, autism, and multiple congenital anomalies. This technology also has applicability in prenatal specimens. To assist clinical laboratories in validation of microarray methodologies for constitutional applications, the American College of Medical Genetics and Genomics has produced the following revised professional standards and guidelines.
Medical subject headings
- Comparative Genomic Hybridization
- Genetic Testing
- Oligonucleotide Array Sequence Analysis
- Prenatal Diagnosis