G1 compartmentalization and cell fate coordination.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24074854.
- Also identified by DOI 10.1016/j.cell.2013.09.015.
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Abstract
Pauklin and Vallier show that, whereas early G1 is permissive for TGF-β-dependent endoderm differentiation, cyclin D restricts the activity of Smad2/3 in late G1, resulting in a switch from endoderm to neuroectoderm potential in pluripotent stem cells. These findings provide insight into how signaling, the cell cycle, and lineage specification are coordinated.
Medical subject headings
- Cell Cycle
- Cell Differentiation
- Cyclin D
- Embryonic Stem Cells
- Signal Transduction