For genomes to stay in shape, insulators must be up to PAR.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24074855.
- Also identified by DOI 10.1016/j.cell.2013.09.012.
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Abstract
Insulators drive nuclear organization by blocking or facilitating interactions between DNA regulatory elements. Ong et al. show that poly(ADP-ribosyl)ation of insulator binding proteins modulates their ability to physically interact with distant regulatory elements, implicating posttranslational modifications of nonhistone proteins in genome architecture.
Medical subject headings
- Chromosomes, Insect
- DNA-Binding Proteins
- Drosophila Proteins
- Drosophila melanogaster
- Insulator Elements
- Poly Adenosine Diphosphate Ribose