DockAFM: benchmarking protein structures by docking under AFM topographs.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24078683.
- Also identified by DOI 10.1093/bioinformatics/btt561 and PMC identifier 5994945.
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Abstract
Proteins can adopt a variety of conformations. We present a simple server for scoring the agreement between 3D atomic structures and experimental envelopes obtained by atomic force microscopy. Three different structures of immunoglobulins (IgG) or blood coagulation factor V activated were tested and their agreement with several topographical surfaces was computed. This approach can be used to test structural variability within a family of proteins. DockAFM is available at http://biodev.cea.fr/dockafm.
Medical subject headings
- Factor V
- Immunoglobulin G
- Microscopy, Atomic Force
- Protein Conformation
- Software