Clinical Cerenkov luminescence imaging of (18)F-FDG.
Level IV
Where this comes from
- Record sourced from PubMed, PMID 24078721.
- Also identified by DOI 10.2967/jnumed.113.127266 and PMC identifier 3903390.
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Abstract
The aim of this study was to determine the feasibility of Cerenkov luminescence (CL) imaging of patients undergoing diagnostic (18)F-FDG scans to detect nodal disease. Patients undergoing routine (18)F-FDG PET/CT for various malignancies consented to being scanned for CL. White-light and Cerenkov images (5-min acquisition) of the surface of the patient contralateral to and at the site of nodal (18)F-FDG uptake were acquired using a cooled, intensified charge-coupled-device camera. The camera demonstrated linear correlation between activity and counts into the low nanocurie range using (18)F-FDG. Imaging of patients revealed the presence of (18)F-FDG uptake in nodes that demonstrated uptake on PET. A correlation between maximum standardized uptake value from PET and counting rate per area on the CL imaging was established. CL imaging with diagnostic doses of (18)F-FDG is feasible and can aid in detecting disease in the clinical setting.
Medical subject headings
- Cohort Studies
- Female
- Fluorodeoxyglucose F18
- Humans
- Luminescence
- Male
- Middle Aged
- Multimodal Imaging
- Multimodal Imaging/methods
- Optical Imaging
- Optical Imaging/methods
- Photons
- Pilot Projects
- Positron-Emission Tomography
- Positron-Emission Tomography/methods
- Radiopharmaceuticals
- Time Factors
- Tomography, X-Ray Computed
- Tomography, X-Ray Computed/methods