Marker-free phenotyping of tumor cells by fractal analysis of reflection interference contrast microscopy images.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24079895.
- Also identified by DOI 10.1021/nl4030402 and PMC identifier 3831548.
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Abstract
Phenotyping of tumor cells by marker-free quantification is important for cancer diagnostics. For the first time, fractal analysis of reflection interference contrast microscopy images of single living cells was employed as a new method to distinguish between different nanoscopic membrane features of tumor cells. Since tumor progression correlates with a higher degree of chaos within the cell, it can be quantified mathematically by fractality. Our results show a high accuracy in identifying malignant cells with a failure chance of 3%, which is far better than today's applied methods.
Medical subject headings
- Cell Tracking
- Fractals
- Microscopy, Interference
- Neoplasms