The road from AKI to CKD: the role of endothelin.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 24080871.
- Also identified by DOI 10.1038/ki.2013.158.
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Abstract
The incidence of acute kidney injury (AKI) is increasing. It is now widely accepted that patients surviving an episode of AKI have a significant risk of progression to chronic kidney disease (CKD) and even end-stage renal failure. Zager and colleagues describe the role of endothelin-1 (ET-1) in the progression of AKI to CKD and provide a basis for the potential use of ET receptor antagonists as a therapeutic strategy in AKI.
Medical subject headings
- Disease Progression
- Endothelin-1
- Kidney Failure, Chronic
- Renal Insufficiency, Chronic
- Reperfusion Injury