Dietary phosphate: the challenges of exploring its role in FGF23 regulation.
other · Level V
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- Record sourced from PubMed, PMID 24080872.
- Also identified by DOI 10.1038/ki.2013.198.
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Abstract
Fibroblast growth factor 23 (FGF23) is an important regulator of phosphate homeostasis, yet efforts to control its circulating levels by manipulating dietary phosphate intake in humans and animals with normal or impaired kidney function have yielded conflicting results. In the study by Zhang et al., severe phosphate restriction in a genetic mouse model of progressive kidney dysfunction failed to cause a uniform FGF23 reduction, again highlighting the complexity of FGF23 regulation.
Medical subject headings
- Acute Kidney Injury
- Fibroblast Growth Factors
- Hypophosphatemia, Familial
- Nephritis, Hereditary
- Phosphates
- Renal Insufficiency, Chronic
- Signal Transduction