Priapism induced by boceprevir-CYP3A4 inhibition and α-adrenergic blockade: case report.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 24092799.
- Also identified by DOI 10.1093/cid/cit673 and PMC identifier 4049070.
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Abstract
A 44-year-old white man presented to the emergency department with a 3-day history of priapism requiring a surgically performed distal penile shunt. A drug-drug interaction is the suspected cause whereby CYP3A4 inhibition by boceprevir led to increased exposures of doxazosin, tamsulosin, and/or quetiapine, resulting in additional α-adrenergic blockade.
Medical subject headings
- Adrenergic alpha-Antagonists
- Cytochrome P-450 CYP3A Inhibitors
- Drug Interactions
- Priapism
- Proline
- Receptors, Adrenergic, alpha