The Semaphorin 3E/PlexinD1 axis regulates macrophage inflammation in obesity.
Level V
Where this comes from
- Record sourced from PubMed, PMID 24093672.
- Also identified by DOI 10.1016/j.cmet.2013.09.011.
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Abstract
Increased accumulation of adipose tissue macrophages in obesity propagates chronic inflammation that is closely associated with insulin resistance and type 2 diabetes. Semaphorin 3E, a guidance molecule for neurons, takes on a new role in obesity by directing the recruitment of macrophages in visceral adipose tissue (Shimizu et al., 2013).
Medical subject headings
- Diet, High-Fat
- Inflammation
- Membrane Glycoproteins
- Nerve Tissue Proteins
- Obesity
- Semaphorins