Hereditary mtDNA heteroplasmy: a baseline for aging?
Level V
Where this comes from
- Record sourced from PubMed, PMID 24093673.
- Also identified by DOI 10.1016/j.cmet.2013.09.015.
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Abstract
Do mtDNA mutations contribute to the aging process, or are they innocent bystanders? Ross et al. (2013) show that inherited mtDNA point mutations lead to a premature aging phenotype in mice and "prime" the maternal lineage, interacting with subsequent somatic mutations to cause brain malformations and shorten lifespan.
Medical subject headings
- Aging
- Brain
- DNA, Mitochondrial
- Extrachromosomal Inheritance
- Mitochondria
- Mutation