A foot in the door: how the chromatin modifier Brg1 and Pax6 jointly potentiate adult neurogenesis.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 24094315.
- Also identified by DOI 10.1016/j.stem.2013.09.013.
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Abstract
Transcription factors and chromatin modifiers are known to contribute to cell specification. However, whether and how they jointly act is poorly understood. In this issue of Cell Stem Cell, Ninkovic et al. show that Pax6 and Brg1 cooperate to modulate gene expression in order to direct neurogenic fate in the olfactory bulb.
Medical subject headings
- Adult Stem Cells
- Eye Proteins
- Gene Regulatory Networks
- Homeodomain Proteins
- Neural Stem Cells
- Neurons
- Paired Box Transcription Factors
- Repressor Proteins
- Transcription Factors