It takes two to tango: Dual inhibition of PI3K and MAPK in rhabdomyosarcoma.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24097859.
- Also identified by DOI 10.1158/1078-0432.CCR-13-2177 and PMC identifier 3828201.
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Abstract
The PI3K/AKT/mTOR and RAS/RAF/MAPK pathways play essential roles in rhabdomyosarcoma. Singular targeting of each pathway is ineffective due to extensive cross-talk and compensatory feedback between these two pathways. Dual blockade with inhibitors of PI3K and MAPK in combination synergistically inhibits growth of rhabdomyosarcoma both in vitro and in vivo.
Medical subject headings
- Mitogen-Activated Protein Kinases
- Phosphatidylinositol 3-Kinases
- Proto-Oncogene Proteins c-akt
- Proto-Oncogene Proteins p21(ras)
- Rhabdomyosarcoma
- Signal Transduction
- TOR Serine-Threonine Kinases