To B or not to B--that is the question for myocardial infarction.

Kim, Nancy D; Luster, Andrew D · Nat Med · 2013

editorial · Level V

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Abstract

After myocardial infarction (MI), circulating B cells produce the chemokine Ccl7, which mobilizes inflammatory monocytes from the bone marrow into the blood, after which they are then recruited to the injured heart, a new study shows. B cell depletion after MI limits myocardial injury and improves heart function, suggesting a new approach for the management of acute MI (pages 1273–1280).

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