Akt2 relaxes podocytes in chronic kidney disease.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 24100980.
- Also identified by DOI 10.1038/nm.3357.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
A signaling cascade is activated in podocytes to induce survival and cope with stress during advanced glomerular disease, a new study shows. The findings may also explain why the immunosuppressor sirolimus, an inhibitor of this pathway, can cause proteinuria in a subset of patients with chronic kidney disease (pages 1288–1296).
Medical subject headings
- Kidney Failure, Chronic
- Podocytes
- Proto-Oncogene Proteins c-akt