T cell activation is determined by the number of presented antigens.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24117051.
- Also identified by DOI 10.1021/nl403266t and PMC identifier 3828117.
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Abstract
Antigen recognition is a key event during T cell activation. Here, we introduce nanopatterned antigen arrays that mimic the antigen presenting cell surface during T cell activation. The assessment of activation related events revealed the requirement of a minimal density of 90-140 stimulating major histocompatibility complex class II proteins (pMHC) molecules per μm(2). We demonstrate that these substrates induce T cell responses in a pMHC dose-dependent manner and that the number of presented pMHCs dominates over local pMHC density.
Medical subject headings
- Antigen-Presenting Cells
- Lymphocyte Activation
- Nanoparticles
- T-Lymphocytes