Rethinking antioxidants in the intensive care unit.
expert_opinion · Level V
Where this comes from
- Record sourced from PubMed, PMID 24117139.
- Also identified by DOI 10.1164/rccm.201307-1380CP and PMC identifier 3919077.
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Abstract
Recently there was yet another clinical trial using antioxidants that failed in patients with critical illness. In this perspective, we suggest that antioxidants likely interfere with the normal immune response, thus contributing to the lack of efficacy in patients with critical illness.
Medical subject headings
- Antioxidants
- Critical Illness
- Oxidative Stress
- Reactive Oxygen Species