Cytosolic reducing power preserves glutamate in retina.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24127593.
- Also identified by DOI 10.1073/pnas.1311193110 and PMC identifier 3831988.
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Abstract
Glutamate in neurons is an important excitatory neurotransmitter, but it also is a key metabolite. We investigated how glutamate in a neural tissue is protected from catabolism. Flux analysis using (13)C-labeled fuels revealed that retinas use activities of the malate aspartate shuttle to protect >98% of their glutamate from oxidation in mitochondria. Isolation of glutamate from the oxidative pathway relies on cytosolic NADH/NAD(+), which is influenced by extracellular glucose, lactate, and pyruvate.
Medical subject headings
- Cytosol
- Glutamic Acid
- Retina