Spatiotemporal drug release visualized through a drug delivery system with tunable aggregation-induced emission.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24129910.
- Also identified by DOI 10.1002/adma.201302365.
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Abstract
Tetraphenylethene and doxorubicin are assembled into a self-indicating drug delivery system (TD NPs). TD NPs are decomposed into DOX and TPE NPs in lysosome. Since TD NPs, TPE NPs and DOX are all fluorescent, the detachment of DOX from TPE NPs is accompanied by fluorescence changing. By observing the fluorescence changes, the spatiotemporal drug release is visualized.
Medical subject headings
- Drug Carriers