Efficient parallel Levenberg-Marquardt model fitting towards real-time automated parametric imaging microscopy.
basic_science · Level V
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- Record sourced from PubMed, PMID 24130785.
- Also identified by DOI 10.1371/journal.pone.0076665 and PMC identifier PMC2640995.
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Abstract
We present a fast, accurate and robust parallel Levenberg-Marquardt minimization optimizer, GPU-LMFit, which is implemented on graphics processing unit for high performance scalable parallel model fitting processing. GPU-LMFit can provide a dramatic speed-up in massive model fitting analyses to enable real-time automated pixel-wise parametric imaging microscopy. We demonstrate the performance of GPU-LMFit for the applications in superresolution localization microscopy and fluorescence lifetime imaging microscopy.