Regulatory T cells prevent liver fibrosis during HIV type 1 infection in a humanized mouse model.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24133182.
- Also identified by DOI 10.1093/infdis/jit548 and PMC identifier 3952666.
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Abstract
Human immunodeficiency virus type 1 (HIV-1) disease is associated with aberrant immune activation, and coinfection with hepatitis C virus (HCV) exacerbates hepatic inflammation and fibrosis. However, the role of HIV-1 infection or host immune modulation in liver pathogenesis is not clearly defined. Here, we report that regulatory T (Treg) cells prevent liver immunopathogenesis during HIV-1 infection in a humanized mouse model. In the absence of Treg cells, HIV-1 infection induced liver fibrosis associated with hepatic stellate cell activation, hepatitis, and liver injury. Our findings provide new insight linking Treg cells and liver immunopathogenesis during HIV-1 infection.
Medical subject headings
- Coinfection
- HIV Infections
- Hepatitis C
- Liver Cirrhosis
- T-Lymphocytes, Regulatory