Fabrication of cysteine-responsive biomimetic single nanochannels by a thiol-yne reaction strategy and their application for sensing in urine samples.

Sun, Zhongyue; Han, Cuiping; Song, Miaomiao; Wen, Long; Tian, Demei; Li, Haibing; Jiang, Lei · Adv Mater · 2014

basic_science · Level V

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Abstract

A photoinitiated thiol-yne click reaction strategy is used to fabricate a novel responsive biomimetic nanochannel platform. It displays a selective response for Cys by way of covalent bond formation on the channel surface. This system can be applied for Cys sensing with high specificity and non-interference performance in complex matrices and human urine samples.

Medical subject headings