Immune activation and the role of TLRs and TLR agonists in the pathogenesis of HIV-1 infection in the humanized mouse model.
review · Level V
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- Record sourced from PubMed, PMID 24151321.
- Also identified by DOI 10.1093/infdis/jit402 and PMC identifier 3807976.
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Abstract
Immune activation plays a critical role in HIV-1 pathogenesis, but the pathways that are responsible for HIV-1-associated immune activation are not well understood. Recent advances in the development of a humanized mouse model for HIV-1 infection might provide new approaches to study the mechanisms of HIV-1 associated immune activation, and to test interventions aimed at reducing HIV-1 pathogenesis.
Medical subject headings
- Disease Models, Animal
- HIV Infections
- HIV-1
- Toll-Like Receptors