Regulatory T cells use "Itch" to control asthma.
Where this comes from
- Record sourced from PubMed, PMID 24162669.
- Also identified by DOI 10.1172/JCI72477 and PMC identifier 3809809.
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Abstract
Regulatory T cells (Tregs) control type 2 T helper cell-mediated (Th2-mediated) lung inflammation, but the molecular mechanisms by which Tregs execute this activity remain elusive. In this issue of the JCI, Jin et al. reveal that Itch, a HECT-type E3 ubiquitin ligase in Tregs, plays a specific role in restraining Th2 cell responses. This finding has important implications for understanding the pathogenesis of allergy and asthma.
Medical subject headings
- Inflammation
- T-Lymphocytes, Regulatory
- Th2 Cells
- Ubiquitin-Protein Ligases