The role of protein kinase CK2 in glioblastoma development.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24166907.
- Also identified by DOI 10.1158/1078-0432.CCR-13-2478 and PMC identifier 3932783.
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Abstract
Glioblastoma is the most prevalent and malignant primary brain tumor in adults, and its response to current therapies is limited. Protein kinase CK2 is overexpressed in glioblastoma and regulates glioblastoma cell survival, proliferation, and migration and brain tumorigenesis. Targeting CK2 for glioblastoma treatment may benefit patients with glioblastoma.
Medical subject headings
- Antineoplastic Agents
- Brain Neoplasms
- Glioblastoma
- Naphthyridines
- Signal Transduction