Targeting metabolic scavenging in pancreatic cancer.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24166909.
- Also identified by DOI 10.1158/1078-0432.CCR-13-2570 and PMC identifier 3930347.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Pancreatic tumor metabolism is rewired to facilitate survival and growth in a nutrient-depleted environment. This leads to a unique dependence on metabolic recycling and scavenging pathways, including NAD salvage. Targeting this pathway in pancreatic cancer disrupts metabolic homeostasis and impairs tumor growth.
Medical subject headings
- Acrylamides
- Antineoplastic Agents
- NAD
- Pancreatic Neoplasms
- Piperidines