Biomolecule delivery to engineer the cellular microenvironment for regenerative medicine.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 24170072.
- Also identified by DOI 10.1007/s10439-013-0932-1 and PMC identifier 4006325.
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Abstract
To realize the potential of regenerative medicine, controlling the delivery of biomolecules in the cellular microenvironment is important as these factors control cell fate. Controlled delivery for tissue engineering and regenerative medicine often requires bioengineered materials and cells capable of spatiotemporal modulation of biomolecule release and presentation. This review discusses biomolecule delivery from the outside of the cell inwards through the delivery of soluble and insoluble biomolecules as well as from the inside of the cell outwards through gene transfer. Ex vivo and in vivo therapeutic strategies are discussed, as well as combination delivery of biomolecules, scaffolds, and cells. Various applications in regenerative medicine are highlighted including bone tissue engineering and wound healing.
Medical subject headings
- Biocompatible Materials
- Cellular Microenvironment
- Drug Delivery Systems
- Regenerative Medicine
- Tissue Engineering
- Tissue Scaffolds