The role of the kidney in protein metabolism: the capacity of tubular lysosomal proteolysis in nephrotic syndrome.
Level V
Where this comes from
- Record sourced from PubMed, PMID 24172729.
- Also identified by DOI 10.1038/ki.2013.284.
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Abstract
The kidneys play an important role in protein metabolism. Renal tubules reabsorb 3 g of albumin under normal conditions, and exhibit a 6-fold increase in the reabsorption of albumin in patients with focal segmental glomerulosclerosis. The capacity of tubular lysosomal proteolysis can be increased up to 8-fold; however, proteinuria over the capacity of tubular handling may cause tubulointerstitial damage in patients with nephrotic syndrome.
Medical subject headings
- Glomerulosclerosis, Focal Segmental
- Kidney Tubules, Proximal
- Lysosomes
- Peptide Hydrolases