Accelerated discovery via a whole-cell model.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24185838.
- Also identified by DOI 10.1038/nmeth.2724 and PMC identifier 3856890.
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Abstract
To test the promise of whole-cell modeling to facilitate scientific inquiry, we compared growth rates simulated in a whole-cell model with experimental measurements for all viable single-gene disruption Mycoplasma genitalium strains. Discrepancies between simulations and experiments led to predictions about kinetic parameters of specific enzymes that we subsequently validated. These findings represent, to our knowledge, the first application of whole-cell modeling to accelerate biological discovery.
Medical subject headings
- Computational Biology
- Models, Biological
- Mycoplasma genitalium
- Systems Biology