Synaptic metaplasticity underlies tetanic potentiation in Lymnaea: a novel paradigm.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 24205089.
- Also identified by DOI 10.1371/journal.pone.0078056 and PMC identifier 3812211.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
We present a mathematical model that explains and interprets a novel form of short-term potentiation, which was found to be use-, but not time-dependent, in experiments done on Lymnaea neurons. The high degree of potentiation is explained using a model of synaptic metaplasticity, while the use-dependence (which is critically reliant on the presence of kinase in the experiment) is explained using a model of a stochastic and bistable biological switch.
Medical subject headings
- Lymnaea
- Models, Theoretical
- Neuronal Plasticity
- Neurons