Cardiolipin and the Nlrp3 inflammasome.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 24206659.
- Also identified by DOI 10.1016/j.cmet.2013.10.013.
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Abstract
The Nlrp3 inflammasome is a key controller of the proinflammatory cytokine IL-1β. Iyer and colleagues (2013) demonstrate that Nlrp3 activators promote an interaction between cardiolipin in mitochondria and Nlrp3. Cardiolipin is thus a hydrophobic danger signal that, upon translocation to the outer mitochondrial membrane, activates Nlrp3, promoting inflammation.
Medical subject headings
- Cardiolipins
- Carrier Proteins
- Inflammasomes
- Mitochondria